刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展

慕升君，刘永军，张娜

中国药学杂志 ›› 2016, Vol. 51 ›› Issue (20) : 1721-1725.

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中国药学杂志
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中国药学杂志 ›› 2016, Vol. 51 ›› Issue (20) : 1721-1725. DOI: 10.11669/cpj.2016.20.001
综述

刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展

  • 慕升君，刘永军，张娜*
作者信息 +

Research Progress in Stimuli Responsive Mesoporous Silica Nanoparticles for Cancer Diagnosis and Therapy

  • MU Sheng-jun, LIU Yong-jun, ZHANG Na*
Author information +
文章历史 +

摘要

参考近期相关文献，对pH、还原、温度、光、磁、生物分子等刺激响应型介孔二氧化硅纳米粒药物递送系统研究进展进行归纳总结。综述刺激响应型介孔二氧化硅纳米粒药物递送系统在肿瘤诊断治疗中的研究进展，并对其应用前景进行展望。刺激响应型介孔二氧化硅纳米粒药物递送系统可解决介孔二氧化硅纳米粒药物释放难以控制的问题，并实现肿瘤定位释药，在肿瘤诊断及治疗方面成为目前研究热点。

Abstract

Referring to the recent literatures, this review summarized the recent research progress of SR-MSNDDS which were responsive to different stimulus, including pH, reduction, temperature, light, magnetic field or biomolecules, etc. To review the recent research progress of stimuli responsive mesoporous silica nanoparticle (SR-MSNDDS) drug delivery systems and predict their application prospect. SR-MSNDDS could overcome the problem of controlling drug release from MSN and achieve tumor specific drug release, which has become a research hotspot in the field of tumor diagnosis and therapy.

关键词

介孔二氧化硅 / 控制释放 / 药物递送 / 肿瘤治疗

Key words

mesoporous silica nanoparticle / controlled release / drug delivery / cancer therapy

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导出引用
慕升君，刘永军，张娜. 刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展[J]. 中国药学杂志, 2016, 51(20): 1721-1725 https://doi.org/10.11669/cpj.2016.20.001
MU Sheng-jun, LIU Yong-jun, ZHANG Na. Research Progress in Stimuli Responsive Mesoporous Silica Nanoparticles for Cancer Diagnosis and Therapy[J]. Chinese Pharmaceutical Journal, 2016, 51(20): 1721-1725 https://doi.org/10.11669/cpj.2016.20.001
中图分类号： R944   

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基金

国家自然科学基金资助项目(81573368);山东大学基本科研业务费(人才引进与培养类专项)资助项目(2015GN019)
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